By Calley, The Cosmetology Nurse
You might have seen the word Polynucleotides popping up on TikTok, in clinic menus, or even heard influencers raving about them — but what actually are they? And how do they compare to skin boosters like Profhilo?
At The Cosmetology Nurse, we’re all about cutting through the hype to deliver results backed by science. So let’s break down the buzz, explain how polynucleotides work, and help you figure out whether they’re right for your skin.
What Are Polynucleotides
Polynucleotides are bio stimulating molecules derived from purified DNA fragments, typically sourced from salmon or trout (don’t worry — they’re highly refined and sterile). When injected into the skin, they act like a cellular repair kit — stimulating fibroblasts, encouraging cell renewal, and reducing inflammation.
In short: they wake up your skin’s natural regeneration processes.
How Are They Different From Profhilo?
It’s easy to confuse polynucleotides with skin boosters like Profhilo, but they work very differently:
Profhilo: A highly concentrated hyaluronic acid (HA) that hydrates, improves elasticity, and remodels tissue. Think of it like a “drink of water” for the skin.
Polynucleotides: These don’t hydrate directly like HA — instead, they stimulate your skin to repair, rebuild and regenerate over time. Think long-term collagen and elastin stimulation, not just a quick moisture boost.
Who Are Polynucleotides Best For?
This treatment is ideal for clients who want to improve:
Skin texture and tone
Fine lines and crepey skin
Dark circles and under-eye quality
Inflammation, sensitivity or redness
Scarring or post-acne healing
They’re also fantastic for younger clients starting early prevention, or anyone who’s had lots of HA-based treatments and wants to focus on deep, regenerative skin health.
How Many Sessions Do You Need?
Polynucleotide treatments work best in a course of 3-4 sessions spaced around 2-3 weeks apart. Results build gradually, with maximum benefit seen around 2–3 months in. We often combine them with other skin treatments like microneedling, LED, or toxin for a layered, skin-first approach.
Are They “Better” Than Profhilo?
Not necessarily better — just different.
Profhilo is incredible for hydration and skin glow, especially if you’re dry, dull or experiencing loss of elasticity. Polynucleotides, however, are better for healing, firming, and regeneration — and they’re especially beneficial for under-eye areas, where most other injectables can’t go safely.
At The Cosmetology Nurse, we’ll always help you choose what’s right for your skin, whether that’s Profhilo, Polynucleotides, or a bespoke combination of both.
Ready to Try Regenerative Skin Medicine?
Polynucleotides are one of the most exciting advancements in regenerative aesthetics — and we love them because they support long-term skin health, not just surface-level changes.
If you’re ready to go deeper and invest in your skin’s future, book a consultation and let’s create a plan that works for you.
We’ll explain everything in plain English, review your skin concerns, and walk you through what to expect — so you can make an informed choice with confidence.
